Overview

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Movement disorders are characterized by multiple manifestations including but not limited to difficulty moving (walking), speaking and swallowing, twitching or jerking movements, even convulsions, that sometimes can be accompanied by loss of consciousness.¹ Because the warning signs of a crisis are not always present or reliably perceived by the patient, there is a need for sensors (wearable, implantable or patch among others) that could detect the warning signs. In this way, the patient would be alerted to an upcoming episode, thereby enabling the patient to take proactive steps such the intake of a medication with fast onset of action.

Challenge

Can we use digital technologies to find a reliable way to predict if a patient is going to have a movement crisis early enough such that the patient is able to take pre-emptive action? Please note that warning signs indicating that a crisis is imminent may include ‘aura’ (pro-drom), psychic symptoms, auditory hallucinations, olfactory hallucinations, numbness, anxiety among others. The solution should allow patients to continue their normal lives with no to minimal interference and may involve all relevant stakeholders in the patient care value chain.

¹Abdo, W., van de Warrenburg, B., Burn, D. et al. The clinical approach to movement disorders. Nat Rev Neurol 6, 29–37 (2010). http://doi.org/10.1038/nrneurol.2009.196

Overview

Patients suffering from a cognitive and behavioural disorders with a neurological involvement, regardless of whether it has neurodevelopmental¹ (ASD, ADHD, NLD,…), neurodegenerative² (Alzheimer, dementia,..), brain injuries, or tumours origins, heavily rely on their caregivers and therapists for support on daily chores. Typically, therapeutical assistance goes to task for rehabitation of impairments as:  vision loss, visuospatial or balance disorders, verbal expression and communicative difficulties, attention or memory deficits, or effective and social skills problems. Digital solutions for these disorders currently focus on cognitive stimulation through games and tests, while solutions that reduce patients’ dependence from caregivers and therapists between patient and doctor, as well as a better quality of life.

Challenge

We would be looking at solutions that allow patients to connect with and leverage relevant stakeholders, to offer more personalized and intensive treatments, to achieve more independence and improved relationships. Can we use digital technologies to help patients with cognitive and behavioural disorders to improve social adaptation, and vital expectations, while reducing their reliance on caregivers and improving their quality of life?

1. The first sub-challenge concerns adult patients with alterations in brain functions due to degenerative processes (dementia, Alzheimer's...), cerebrovascular accidents (ABI), traumas (accidents) or tumour processes. The solution would have to include cognitive rehabilitation or behavioural reeducations programs or treatments to improve their adaptabilities skills and so their performance in life.

2. The second sub-challenge is oriented towards neurodevelopmental disorders (including but not limited to autism spectrum disorders, hyperactivity and attention deficits, language disorders, among others) in children & adults. The solution would be a digital approach for rehabilitation interventions for cognitive impairment attention focus, memory, learning and language development, social skills) and for the associated behavioural or emotional disorders it may also be a treatment of related symptoms (aggressiveness, negativity).

¹http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(16)30376-5/fulltext

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Pain is a psychosomatic response dependent on an objective component (the strength of sensory signal sent to the brain) and a subjective component (a combination of cognitive, emotional and behavioural response) that affects how the pain is perceived and reported.¹ As a result, not only patient’s response to pain medication is highly variable but patient’s self-reporting of pain may also be erratic and unreliable making it difficult for the doctor to decide on optimal drug dosage.² This challenge aims at finding digital technologies for optimal dose-adjustment of pain medications, including opioid treatments, where there is a need to guarantee enough comfort to the patient while reducing the risk of adverse events.

Challenge

Can we improve pain management of patients, including those that rely on opioids, using digital technologies? Can we help doctor-patient relationship and communication by objectivizing reporting of pain? The solution should present a systematic and measurable approach to pain management involving all relevant stakeholders.

1. The first sub-challenge looks at how to predict, detect and reduce opioid misuse to prevent dosage escalation? The solution would involve monitoring the actual dose (i.e. surrogate marker for the concentration of drug in the patients’s body) vs. the actual need of the patient (i.e. captured through digital pain biomarkers). The goal being to ensure that the patient is not under-treated and, at the same time, is not bearing pain.

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¹http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438523/

²http://www.ncbi.nlm.nih.gov/pubmed/24051610